Aspirin may prevent deadly blood clots

Low-dose aspirin is a cheap and effective way to prevent potentially deadly blood clots in the leg, or the lungs in patients who have had a previous blood clot, a new study shows.

The study, conducted by the National Health and Medical Research Council’s Clinical Trials Centre at the University of Sydney, and a team of international investigators, was published recently in The New England Journal of Medicine.

The study found people who have suffered blood clots in the veins of the leg (deep vein thrombosis or DVT) or the lungs (pulmonary embolism or PE) are less likely to suffer a recurrence of the serious blood clots, or a cardiac event if they take low-dose aspirin. These conditions affect about one in 1,000 people in Australia each year.

“The results of this study suggest the simple, inexpensive treatment of low-dose aspirin could prevent thousands of patients from experiencing recurrent clots each year and may make substantial healthcare savings in Australia and worldwide,” Professor John Simes, director of the NHMRC Clinical Trials Centre at the University of Sydney and chair of the study, said.

“These results suggest aspirin prevents about one third of recurrent blood clot events. For every 1,000 patients treated for one year, aspirin can be expected to prevent about 20 to 30 episodes of recurrent major thrombotic events at the cost of about three significant bleeding episodes.”

Operating since 2003, the ASPIRE study completed recruitment of 822 participants from five countries including Australia, New Zealand, Singapore, India and Argentina. All the participants had previously suffered a DVT or PE that occurred for no particular reason, called ‘unprovoked VTE’ (venous thromboembolism).

They had completed on average six months of anti-coagulant treatment, generally with warfarin. They were randomly allocated to receive either low dose enteric coated aspirin or a matching placebo. On average participants were followed for three years.

Dr Tim Brighton, from Prince of Wales Hospital and principal investigator of the study, explained: “Many patients discontinue warfarin therapy after six or 12 months of treatment due to the inconvenience of regular blood tests and the increased risks of serious bleeding [putting them at high risk of recurring thrombosis].”

Aspirin reportedly reduces the risk of important blood clotting event including recurrent VTE, myocardial infarction, stroke, or cardiovascular death.

A study earlier this year revealed seniors suffering from virtually any type of infection are more likely to be hospitalised for dangerous blood clots in their deep veins or lungs.