Research could lead to Alzheimer’s drugs
New insights into how nerves cells in the brain maintain efficient communication with each other may help offset the effects of Alzheimer’s disease.
Australian research has identified the process responsible for regulating neuronal communication, which is crucial for learning and memory.
The work aims to build a foundation for the future identification and development of drugs to treat Alzheimer’s.
Dr Victor Anggono, of the Clem Jones Centre for Ageing Dementia Research at the Queensland Brain Institute, says cognitive decline such as memory loss could be minimised if receptors in the central nervous system could be maintained at healthy levels.
“Communication in the brain comes down to nerve cells’ ability to send messages chemically to one another. When impaired, they will not transmit information as efficiently as they should,” Dr Anggono says.
“This all happens very quickly – in milliseconds – allowing memory to be coded or retrieved. In the case of Alzheimer’s disease, there is a pretty good consensus that this transmission is disturbed, partly due to the loss of the receptors,” he adds.
“If we can reduce the damage to these receptors then we may be able to compensate for the adverse effects of toxic clumps, known as amyloid beta, that build up around nerve cells and disrupt neuronal communication in Alzheimer’s disease.”
Using DNA technology, the researchers discovered they could modify the stability of the receptors in a lab setting, and will now move towards testing these 're-engineered' receptors in mice.
“Hopefully we can see an improvement in learning and memory, and if we see that then we’ll be hopeful that this strategy could work to slow the cognitive decline associated with Alzheimer’s disease,” Dr Anggono says.
Impaired receptor function has also been linked to many neuropsychiatric disorders such as schizophrenia and depression.
The research is funded by John T. Reid Charitable Trusts, the International Human Frontier Science Program, and the Australian National Health and Medical Research Council (NHMRC), and completed in collaboration with the John Hopkins University School of Medicine.
