Hopes for cure in humble mouse
Hopes for a cure for many brain diseases may rest on the humble mouse, now that scientists can map the rodents’ brains more thoroughly than ever before.
Hopes for a cure for many brain diseases may rest on the humble mouse, now that scientists can map the rodents’ brains more thoroughly than ever before.
Researchers at The University of Queensland’s Centre for Advanced Imaging (CAI) and Curtin University have created a detailed atlas of the mouse brain, a development that is helping in the fight against brain disease.
This new tool may allow researchers to map what parts of the brain are affected in mouse models of brain disease – such as brain cancer, Parkinson’s disease and Alzheimer’s disease, which affect nearly one in six of the world’s population.
Lead author, Dr Jeremy Ullmann, said the new brain atlas provided a fundamental tool for the neuroscience community.
“The mouse is now the most widely used animal model for neuroscience research and magnetic resonance imaging (MRI) is fundamental to investigating changes in the brain,” Dr Ullman said.
“Our atlas is already much in demand internationally because it allows researchers to use MRI to automatically map brain structures.”
The atlas was created in the laboratory of Professor David Reutens, CAI director.
“In making these worldfirst maps, we had the advantage of using the most powerful MRI scanners in the Southern Hemisphere, backed up by leaders in digital image analysis, resulting in remarkably clear images of the brain,” Professor Reutens said.
The project’s lead neuroanatomist, Professor Charles Watson, from Curtin University, believes that the study will open the door to accurate analysis of gene targeting in the mouse brain.
“The invention of gene targeting in the mouse has made this species the centrepiece of studies on models of human brain disease. MRI allows researchers to follow changes in the brain over time in the same animals,” Professor Watson said.
