Family heart problems probed
Links between family heart problems and irregular heart beats have been examined by the Victor Chang Cardiac Research Institute and may lead to more effective treatment.
Atrial fibrillation is the most common heart rhythm abnormality in the community and is a major risk factor for stroke and heart failure. Recent studies suggest that inherited gene changes in families are an important cause of atrial fibrillation, but what these genes are, and how changes in genes can promote heart rhythm abnormalities, are unknown.
Victor Chang Cardiac Research Institute researchers have found that interactions between inherited gene changes and stretch or dilatation of the low pressure upper chambers of the heart, the atria, may be important in the onset of atrial fibrillation. The work suggests that aggressive treatment of underlying conditions – such as high blood pressure which causes atrial enlargement – may prevent the onset of atrial fibrillation.
Atrial fibrillation is a type of heart disease, termed a cardiac arrhythmia, where the heart beats in an irregular and often rapid rhythm. The abnormal beating results in poor blood flow and an increased risk of developing a stroke or heart failure. It is the most common cardiac arrhythmia, affecting 2% of Australians and 1 in 10 people over 80. Yet while many Australians are afflicted with this form of heart disease, little is understood about its causes up till now.
