Alzheimer’s brain scan
A brain scan to detect Alzheimer’s disease could be available in hospitals worldwide within the next year and could boost efforts to detect the degenerative and fatal condition, Australian experts say.
A brain scan to detect Alzheimer’s disease could be available in hospitals worldwide within the next year and could boost efforts to detect the degenerative and fatal condition, Australian experts say.
The technique, known as a positron emission tomography (PET) scan, can find and analyse a protein known as beta-amyloid, which is linked to Alzheimer’s.
“Amyloid imaging with PET scans is expected to be widely available soon for clinical practice,” said Christopher Rowe, a professor of nuclear medicine at Austin Hospital in Victoria.
“It will be an important new tool in the assessment of cognitive decline.”
The results from three studies on advances in PET scans for Alzheimer’s were presented at a meeting of the Society for Nuclear Medicine’s annual meeting in San Antonio, Texas.
Researchers said the new methods would be of growing importance as the world population ages, and could provide clues toward treating Alzheimer’s. There is no known cure.
About 18 million people worldwide suffer from Alzheimer’s, the most common form of dementia.
“From a macro perspective, amyloid imaging with PET scans can help to ascertain the likelihood that individuals will deteriorate cognitively within a few years, thereby enabling more efficient channelling of health care resources,” said Kevin Ong, a research scientist at Austin Hospital in Melbourne.
“From a micro perspective, planning and lifestyle modifications are possible for individuals who seek screening for Alzheimer’s disease.”
Such scans could find clues of the onset of Alzheimer’s long before symptoms present. Previous research has shown that the disease can begin as much as decade before signs of dementia appear.
Amyloid plaque is found in the brains of healthy older people and builds up over time. Larger, faster build-up is linked to quicker memory decline and wasting away of brain tissue.
Amyloid plaques typically grow by about 2%-3% per year, and are found in about 12% of people in their 60s, 30% of those in their 70s and 55% of people over age 80, the researchers said.
The studies presented spanned several years of research and involved hundreds of patients at all stages of cognitive function.
Two of the studies suggested imaging agents known as F-18 labelled tracers, F-18 Florbetaben and F-18 Florbetapir, are the most likely to move into clinical practice in the near term.
